My OperaThis is the default title.
Wednesday, January 16, 2013 8:59:51 AM
1, 3 Dimethylamylamine: The Supplement For Intelligence, Weight Reduction, and Body Building
The supplement 1, 3 Dimethylamylamine, also know as Geranamine, DMAA, Methylhexaneamine, Geranium Extract, and many times simply 1, 3 Dymethyl for short, is an efficient nootropic stimulant, made use of by students, weight lifters, body builders, and even people hoping to lose weight. Notorious as it may be, DMAA is completely accepted and positively safe.Effects of DMAADMAA has been proven to be an extremely effective nootropic in regards to elevated energy levels and also increased concentration. An average dose of about 25-50 milligrams is able to remain effective for five hours and usually comes with minor to no side effects. Different to caffeine, DMAA manages without producing jitters and it does not leave the human body feeling drained after the effects wear off. This nootropic is typically regarded to be cleaner by health professionals, producing zero increase in toxicity inside the human body.Students and individuals battling ADHD have realized Geranamine to generally be a beneficial answer. The nootropic supplement performs to elevate mental liveliness and concentration, enabling people to complete long, intellectually difficult duties, with increased awareness. 1 3 Dimethylamylamine functions to breakdown fat in your body and supply you with the life energy you need. DMAA furthermore benefits mood and also provides the user with a feeling of overall well being.In regards to burning fat, DMAA is extremely potent. The supplement is commonly displayed as the primary element for popular fat burning supplements available on the market today. 1 3 dimethylamylamine works as a thermogenic, meaning it enhances the body's natural calorie burning metabolism and transforms the fat into energy. As a matter of fact, that is where the intellectual and also physical strength are arising from. Utilizing a supplement which contains DMAA won't sustain your body solely, but it surely may take your diet plan to the next level.Weightlifters and fitness buffs utilize this substance for related reasons. 1) It presents them with a jolt of energy that is great for maximizing the amount of extra pounds they can lift. And 2) it's a fat loss supplement or "cutter" like bodybuilders prefer to refer to it as. It assists them shed the extra fat that exercising couldn't exterminate, exposing his or her muscles in more defined way and boosting athletic performance.Is 1, 3 Dimethylamylamine Banned?Its trully amazing effectiveness with regard to pushing athlete's abilities has triggered it into being banned by a few sports groups. Its usually singularly disallowed on the day of tournament, but is in fact allowed for off season training because it works so well. Make sure to check with your particular sport organization before taking on the actual day you will be to get tested.Geranamine Side Effects?Usually the side effects are few, rare, and also different. They primarily only enhance complications with the unhealthy. Some sarse collected side effects have been shortage of sleep, loss of appetite, and headaches. On even more scarce incidences individuals have reported to feel queasy, although that typically coincides with a poor diet or taking on a very empty stomach. ============================== NEW ARTICLE ==============================DMAA VS Caffeine
See all 3 photos
DMAA and CaffeineCaffeine and DMAA are stimulants. Stimulants are drugs that
temporarily increase mental and physical function. Caffeine is a mild stimulant
found in coffee, tea, soda, and energy drinks. DMAA is a more powerful
stimulant used as an ingredient in several pre workout supplements and weight
loss pills.Stimulants are Psychoactive DrugsA psychoactive drug acts upon your central nervous system to
alter your brain function. This results in a change in mood, behavior, and
cognition. The boost in mood caused by stimulants is the primary reason why
they can be addictive.
Regular coffee drinkers first get into the routine of a
daily cup once they experience the boost in mood that caffeine provides. As
they continue to drink coffee and their tolerance builds, they have to drink
more to experience the same effect. Another reason this habit starts is because
some may not feel fully awake without their daily caffeine. This habituation is
reinforced by caffeine tolerance.
Even though caffeine is one of the safest of all stimulants,
it still poses a risk because you can develop dependence. This dependence
results in restlessness and needing more caffeine to feel awake or experience
the caffeine "buzz".
See all 3 photos
DMAA in SportsTrack and field athletes take stimulants before a meet to
increase focus and energy. Mild stimulants such as caffeine are allowed in
professional sports, but more powerful stimulants are prohibited by the World
Anti-Doping Agency.
Methylhexanamine, or DMAA, is legal in the US, but its use is
prohibited in professional sports. This doesn't stop athletes from using DMAA
during training or taking it before competitions where drug tests aren't
administered.
Bodybuilders take DMAA to increase their focus and strength
in order to increase their lifts and training intensity. Supplement companies use
DMAA in their pre workout formulas, such as USP Labs Jack3d and Scivation Quake 10.0.Recreational Use of DMAAInstead of taking DMAA to increase performance or focus,
some just enjoy the euphoric sensation experienced 30-45 minutes after taking
DMAA orally. Recent outlawing of party drugs, such as BZP, has led to the use
of DMAA as a legal substitute.
DMAA's popularity in New Zealand has led to its restriction.
DMAA in New Zealand must be sold in pill or capsule format and cannot exceed
25mg. In other countries and in the US, this restriction doesn't exist and you
may still purchase DMAA powder. If you do decide to buy DMAA powder, make sure you have a
milligram-sensitive scale, and only start with 25mg doses to gauge your
tolerance level before graduating to higher doses.Strength of DMAA vs. CaffeineAs far as strength, DMAA is a more powerful stimulant than
caffeine. This means that a smaller amount of DMAA is required to experience
more profound stimulant effects. DMAA benefits include elevated mood, energy,
and confidence.
Caffeine kicks in 5-15 minutes after consumption, whereas
DMAA does not take effect until 30-45 minutes later. The boost in energy from
caffeine generally lasts 1 to 3 hours, and healthy adults metabolize half of
their consumed caffeine within 6 hours. The effects of DMAA last anywhere from
2 to 5 hours depending on your tolerance level.
The crash associated with caffeine usually results in
extreme fatigue and irritability. DMAA lasts 2 to 4 hours and doesn't result in
the usual crash. Instead, as DMAA wears off, it leaves you feeling calm and
mellow. DMAA and Caffeine Side EffectsSide effects from caffeine include increased urination, dry
mouth, irritability, flushing, and anxiety. DMAA has similar side effect as
caffeine, but the chance of increased anxiety is reduced and flushing of the
skin is more common. Both stimulants can cause insomnia if abused.
See all 3 photos
Caffeine side effects
============================== NEW ARTICLE ==============================Stimulant in sports supplements is not natural as marketed ...
With the increased awareness of the value of healthy lifestyles for overall good health sports supplements have become more and more popular. When buying these supplements the consumer is often at the mercy of the marketers to help determine if they are really all natural and healthy. A new study has found that a stimulant marketed as natural in sports supplements is not natural as marketed. Science Daily has reported "Stimulant Marketed as 'Natural' in Sports Supplement Actually of Synthetic Origin, Study Suggests."View slideshow:
Enjoying sports drinks
A new study which has been published in the journal Drug Testing and Analysis has found that DMAA, which is a stimulant often found in many nutritional and sports supplements, does not originate from natural substances and is actually composed of synthetic compounds. This substance DMAA (1,3-dimethylamylamine) is a stimulant which exists in various pre-workout supplements and is often labeled as part of geranium plants. The safety and origin of DMAA in these supplements has been the subject of intense debate and has recently been linked to the deaths of two U.S. soldiers, leading the Army to pull the supplement from its commissaries.
Daniel W. Armstrong, Ph.D., of the University of Texas at Arlington, led a research team which set out to determine the unique isomeric ratios of synthetic substances (DMAA) and natural substances which are distinctly different and therefore can be used in order to distinguish between the two. The researchers found that DMAA actually consists of 4 different compounds which are called stereoisomers and that the unique isomeric ratios in synthetic DMAA were the same as those found for the DMAA in all supplements.
Therefore, the DMAA in supplements did not have originate from the geranium plant. Armstrong has said "The FDA should regulate and/or ban products in which significant amounts of synthetic pharmacological compounds are added. Also, this information should be clearly labeled -- including their effects and possible side effects -- so that consumers can make an informed choice. In the meantime consumers who are aware of this problem can make more informed decisions about the use of sports supplements with DMAA.
Mandel News Service
============================== NEW ARTICLE ==============================Bitter Orange: An Alternative to DMAA
On April 27, 2012, the U.S. Food and Drug Administration issued a warning letter to 10 fitness supplement companies selling weight loss and sports nutrition products containing the controversial ingredient, DMAA. The FDA further warned that DMAA was not a botanical ingredient since it is synthetically produced and therefore ineligible to be used as an active ingredient in a dietary supplement. Citing several harmful effects of DMAA, the FDA ordered said companies to immediately take remedial steps to address these concerns.1
What are the Side Effects of DMAA?DMAA, commonly sold as 1,3- dimethylamylamine, methylhexanamine, or geranium extract, is a synthetic substance popularly used in bodybuilding and weight-loss products. DMAA is said to have potentially fatal side effects on cardiovascular health leading to events such as shortness of breath, tightening of chest, heart attacks and elevated blood pressure. After 42 public complaints, the FDA issued a warning linking DMAA to serious health effects on the nervous system and psychiatric disorders as well as death.2The controversy: Is DMAA a Drug?The controversy over DMAA doesn’t end here. Is DMAA a botanical substance or synthetic? Since DMAA is manufactured in laboratories, many experts believe it is not a botanical substance, but an amphetamine-like substance which should be treated as a drug. It should undergo rigorous testing standards and be approved by the FDA as a drug. In light of these heated controversies, supplement business owners are busy looking for safer substitutes for DMAA in their weight-loss and sport nutrition formulations. One option is to substitute DMAA with the herbal substance, bitter orange, as their benefits are similar.Health Benefits of Bitter OrangeBitter orange is prepared from the bitter orange fruit, botanically known as Citrus aurantium. For centuries the Chinese and the tribes of the Amazon rainforests have used it to treat indigestion, nausea and constipation. Bitter orange supplements are believed to treat heartburn, appetite loss, nasal congestion, weight loss and fungal infections. The two bioactive ingredients in bitter orange are synephrine and octopamine. Both are stimulants that help to increase rate of body metabolism.3However, because its chemical structure is similar to ephedra, some people mistakenly believe that bitter orange has the same negative side effects as ephedra. Bitter orange contains the active compound p-synephrine. Does p-synephrine have the same dangerous side effects as ephedra? Let’s find out.Is P-Synephrine Dangerous?Hundreds of studies report the safety and efficacy of p-synephrine. An abstract from “A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects” published in the 2011 Volume of Oxidative Medicine and Cellular Longevity states:4“Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of p-synephrine are widely assumed to be similar to those of ephedrine, m-synephrine (phenylephrine), and endogenous amine neurotransmitters as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-spread consumption of p-synephrine in the form of dietary supplements as well as in various Citrus foods and juices. This paper summarizes the adrenoreceptor binding characteristics of p-synephrine relative to m-synephrine, norepinephrine, and other amines as related to the observed pharmacological effects.”Another extensive study highlights the reasons for the confusion about bitter orange:5“Current confusion regarding the safety and efficacy of bitter orange extract and p-synephrine is clouded by multiple issues, including the use of complex mixtures of ingredients in products that include bitter orange extract, the release of misleading information by governmental agencies, and misunderstandings regarding the isomeric forms of synephrine and their differing pharmacological properties. In addition, the projected warnings regarding cardiovascular risks are extrapolated from studies involving m-synephrine and ephedrine which are not components of bitter orange extract, and from studies involving the intravenous administration of p-synephrine at concentrations that are not attained by oral ingestion in foods or supplements.”The study goes on to reveal a few more valid points: 6“A final consideration regarding the safety of p-synephrine is the exposure of millions of people who daily consume, without ill effect, various juices and food products as marmalade from Citrus species asSeville orange, grapefruit, mandarin and other orange-related species that contain p-synephrine.7A typical sweet orange contains about 6mg p-synephrine.8A wide variety of Citrus juices contain approximately 5mg p-synephrine per 8 ounce glass.9A U.S. Department of Agriculture study of the p-synephrine content of mandarin orange juice from 10 different groves in California found that the p-synephrine content ranged from 73 to 158 mg/L, with an overall mean of 93 mg/L.10Another study has shown the juice from Clementines, a variety of mandarin oranges, contained on average of 114mg p-synephrine/L while Marrs sweet oranges yielded 85 mg/L.11Therefore, consuming an 8 ounce glass of mandarin orange juice may deliver as much as 40mgP-synephrine, similar to the amount of p-synephrine in the typical dietary supplement.”Bitter orange: An effective substitute forDMAAin your supplement formulations.Bitter orange is the ideal replacement for DMAA in your weight loss or sports nutrition products. Find a reliable LINK REMOVED supplement manufacturerEND LINK REMOVED that has a track record of contract manufacturing success. A supplement manufacturer with an award-wining history will ensure you get products that stand out in the marketplace. Look for optional manufacturing solutions such as label design, packaging options, order fulfillment and storage options that can it make it convenient for you to manufacture your product.Resources:FDA challenges marketing of DMAA products for lack of safety evidence, April 27, 2012. fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302133.htmIbid.Bitter Orange, Drugs.com. drugs.com/npp/bitter-orange.htmlA Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects, Oxidative Medicine and Cellular Longevity Volume 2011 (2011), Article ID 482973, 9 pages, doi:10.1155/2011/482973. hindawi.com/journals/oximed/2011/482973/abs/The Safety of Citrus aurantium (Bitter Orange) and its Primary Protoalkaloid p?Synephrine, PHYTOTHERAPY RESEARCH, Phytother. Res. (2011), Published online in Wiley Online Library(wileyonlinelibrary.com) DOI: 10.1002/ptr.3490. nutratechinc.com/advz/UploadedFiles/Phyto%20Research%200411.pdfIbidPellati et al.,2002, 2004, 2005; Blumenthal, 2004; Avula et al., 2005; Mattoli et al., 2005; Dragull et al., 2008; Arbo et al., 2008; Roman et al., 2008.Mattoli et al., 2005.Blumenthal, 2004; Pellati et al., 2002, 2004, 2005.Dragull et al., 2008.Uckoo et al.,2010. Nutricap Labs is a full service LINK REMOVED contract manufacturing nutritional supplementsEND LINK REMOVED . We primarily manufacture GMP-certified capsules, powders, liquids and creams.
============================== NEW ARTICLE ==============================Product Liability Insurers To Exclude DMAA From Coverage
(Los Angeles, CA): More trouble for DMAA, the controversial ingredient in many pre-workout sports nutrition and weight loss products.
Greg Doherty, Practice Leader of the dietary supplement insurance division of Poms & Associates Insurance Brokers, Inc, today announced that two of the handful of companies offering product liability coverage to the dietary supplement industry will soon be adding DMAA to their respective “ingredient exclusion†list.
“I predicted this over a year ago, and now it’s happening†says Doherty. “There has been too much negative press lately on DMAA, and eventually it was bound to catch the eye of some of the insurance company underwriters. Two carriers will now exclude it, although one has hinted that they may offer coverage for products containing DMAA on a “carveback†basis, which means that based on the type of products being sold, the dosage of DMAA and the volume of DMAA sales as a percentage of overall sales, this carrier might offer DMAA coverage for an additional premium. The key word is ‘might.’ “
Doherty further noted that as ephedra alkoloids got more and more bad press, these “carvebacks†granting coverage were available, but eventually coverage was excluded altogether. Subsequently, the insurance companies paid out millions of dollars for ephedra claims, and they have not forgotten that fact.
“As of right now coverage is still available for DMAA products from other insurers, but my opinion is that the window is closing. It’s really the ephedra insurance coverage story all over again.â€
“Companies currently selling DMAA and want it to be covered in the future face a real dilemma,†Doherty adds. “Because of the claims made nature of product liability policies for dietary supplement companies, the product you sell today will likely not produce a claim until some date in the future. If your future policy has a DMAA exclusion, and that claim rolls in, there won’t be coverage, even though the policy in your file today covers DMAA.â€
When it comes to an in-depth understanding of the dietary supplement industry, Greg Doherty is Poms & Associates’ mega-multi vitamin of knowledge, experience and reliability.
Just like you've heard the radio commercial say, “When banks compete you win.†we say “When insurance companies compete for your business, you win.†If you’re in the supplement industry, and want to be sure that your company has the best possible product liability insurance, and experience the personal service you deserve, call Greg directly at 818-449-9317
Greg M. Doherty is a commercial insurance broker based in Los Angeles. He is a specialist on the subject of DMAA exclusion. Doherty can be reached at (818) 449-9317 or gdoherty@pomsassoc.com Website: http://www.gregdoherty.net
============================== NEW ARTICLE ==============================
The supplement 1, 3 Dimethylamylamine, also know as Geranamine, DMAA, Methylhexaneamine, Geranium Extract, and many times simply 1, 3 Dymethyl for short, is an efficient nootropic stimulant, made use of by students, weight lifters, body builders, and even people hoping to lose weight. Notorious as it may be, DMAA is completely accepted and positively safe.Effects of DMAADMAA has been proven to be an extremely effective nootropic in regards to elevated energy levels and also increased concentration. An average dose of about 25-50 milligrams is able to remain effective for five hours and usually comes with minor to no side effects. Different to caffeine, DMAA manages without producing jitters and it does not leave the human body feeling drained after the effects wear off. This nootropic is typically regarded to be cleaner by health professionals, producing zero increase in toxicity inside the human body.Students and individuals battling ADHD have realized Geranamine to generally be a beneficial answer. The nootropic supplement performs to elevate mental liveliness and concentration, enabling people to complete long, intellectually difficult duties, with increased awareness. 1 3 Dimethylamylamine functions to breakdown fat in your body and supply you with the life energy you need. DMAA furthermore benefits mood and also provides the user with a feeling of overall well being.In regards to burning fat, DMAA is extremely potent. The supplement is commonly displayed as the primary element for popular fat burning supplements available on the market today. 1 3 dimethylamylamine works as a thermogenic, meaning it enhances the body's natural calorie burning metabolism and transforms the fat into energy. As a matter of fact, that is where the intellectual and also physical strength are arising from. Utilizing a supplement which contains DMAA won't sustain your body solely, but it surely may take your diet plan to the next level.Weightlifters and fitness buffs utilize this substance for related reasons. 1) It presents them with a jolt of energy that is great for maximizing the amount of extra pounds they can lift. And 2) it's a fat loss supplement or "cutter" like bodybuilders prefer to refer to it as. It assists them shed the extra fat that exercising couldn't exterminate, exposing his or her muscles in more defined way and boosting athletic performance.Is 1, 3 Dimethylamylamine Banned?Its trully amazing effectiveness with regard to pushing athlete's abilities has triggered it into being banned by a few sports groups. Its usually singularly disallowed on the day of tournament, but is in fact allowed for off season training because it works so well. Make sure to check with your particular sport organization before taking on the actual day you will be to get tested.Geranamine Side Effects?Usually the side effects are few, rare, and also different. They primarily only enhance complications with the unhealthy. Some sarse collected side effects have been shortage of sleep, loss of appetite, and headaches. On even more scarce incidences individuals have reported to feel queasy, although that typically coincides with a poor diet or taking on a very empty stomach. ============================== NEW ARTICLE ==============================DMAA VS Caffeine
See all 3 photos
DMAA and CaffeineCaffeine and DMAA are stimulants. Stimulants are drugs that
temporarily increase mental and physical function. Caffeine is a mild stimulant
found in coffee, tea, soda, and energy drinks. DMAA is a more powerful
stimulant used as an ingredient in several pre workout supplements and weight
loss pills.Stimulants are Psychoactive DrugsA psychoactive drug acts upon your central nervous system to
alter your brain function. This results in a change in mood, behavior, and
cognition. The boost in mood caused by stimulants is the primary reason why
they can be addictive.
Regular coffee drinkers first get into the routine of a
daily cup once they experience the boost in mood that caffeine provides. As
they continue to drink coffee and their tolerance builds, they have to drink
more to experience the same effect. Another reason this habit starts is because
some may not feel fully awake without their daily caffeine. This habituation is
reinforced by caffeine tolerance.
Even though caffeine is one of the safest of all stimulants,
it still poses a risk because you can develop dependence. This dependence
results in restlessness and needing more caffeine to feel awake or experience
the caffeine "buzz".
See all 3 photos
DMAA in SportsTrack and field athletes take stimulants before a meet to
increase focus and energy. Mild stimulants such as caffeine are allowed in
professional sports, but more powerful stimulants are prohibited by the World
Anti-Doping Agency.
Methylhexanamine, or DMAA, is legal in the US, but its use is
prohibited in professional sports. This doesn't stop athletes from using DMAA
during training or taking it before competitions where drug tests aren't
administered.
Bodybuilders take DMAA to increase their focus and strength
in order to increase their lifts and training intensity. Supplement companies use
DMAA in their pre workout formulas, such as USP Labs Jack3d and Scivation Quake 10.0.Recreational Use of DMAAInstead of taking DMAA to increase performance or focus,
some just enjoy the euphoric sensation experienced 30-45 minutes after taking
DMAA orally. Recent outlawing of party drugs, such as BZP, has led to the use
of DMAA as a legal substitute.
DMAA's popularity in New Zealand has led to its restriction.
DMAA in New Zealand must be sold in pill or capsule format and cannot exceed
25mg. In other countries and in the US, this restriction doesn't exist and you
may still purchase DMAA powder. If you do decide to buy DMAA powder, make sure you have a
milligram-sensitive scale, and only start with 25mg doses to gauge your
tolerance level before graduating to higher doses.Strength of DMAA vs. CaffeineAs far as strength, DMAA is a more powerful stimulant than
caffeine. This means that a smaller amount of DMAA is required to experience
more profound stimulant effects. DMAA benefits include elevated mood, energy,
and confidence.
Caffeine kicks in 5-15 minutes after consumption, whereas
DMAA does not take effect until 30-45 minutes later. The boost in energy from
caffeine generally lasts 1 to 3 hours, and healthy adults metabolize half of
their consumed caffeine within 6 hours. The effects of DMAA last anywhere from
2 to 5 hours depending on your tolerance level.
The crash associated with caffeine usually results in
extreme fatigue and irritability. DMAA lasts 2 to 4 hours and doesn't result in
the usual crash. Instead, as DMAA wears off, it leaves you feeling calm and
mellow. DMAA and Caffeine Side EffectsSide effects from caffeine include increased urination, dry
mouth, irritability, flushing, and anxiety. DMAA has similar side effect as
caffeine, but the chance of increased anxiety is reduced and flushing of the
skin is more common. Both stimulants can cause insomnia if abused.
See all 3 photos
Caffeine side effects
============================== NEW ARTICLE ==============================Stimulant in sports supplements is not natural as marketed ...
With the increased awareness of the value of healthy lifestyles for overall good health sports supplements have become more and more popular. When buying these supplements the consumer is often at the mercy of the marketers to help determine if they are really all natural and healthy. A new study has found that a stimulant marketed as natural in sports supplements is not natural as marketed. Science Daily has reported "Stimulant Marketed as 'Natural' in Sports Supplement Actually of Synthetic Origin, Study Suggests."View slideshow:
Enjoying sports drinks
A new study which has been published in the journal Drug Testing and Analysis has found that DMAA, which is a stimulant often found in many nutritional and sports supplements, does not originate from natural substances and is actually composed of synthetic compounds. This substance DMAA (1,3-dimethylamylamine) is a stimulant which exists in various pre-workout supplements and is often labeled as part of geranium plants. The safety and origin of DMAA in these supplements has been the subject of intense debate and has recently been linked to the deaths of two U.S. soldiers, leading the Army to pull the supplement from its commissaries.
Daniel W. Armstrong, Ph.D., of the University of Texas at Arlington, led a research team which set out to determine the unique isomeric ratios of synthetic substances (DMAA) and natural substances which are distinctly different and therefore can be used in order to distinguish between the two. The researchers found that DMAA actually consists of 4 different compounds which are called stereoisomers and that the unique isomeric ratios in synthetic DMAA were the same as those found for the DMAA in all supplements.
Therefore, the DMAA in supplements did not have originate from the geranium plant. Armstrong has said "The FDA should regulate and/or ban products in which significant amounts of synthetic pharmacological compounds are added. Also, this information should be clearly labeled -- including their effects and possible side effects -- so that consumers can make an informed choice. In the meantime consumers who are aware of this problem can make more informed decisions about the use of sports supplements with DMAA.
Mandel News Service
============================== NEW ARTICLE ==============================Bitter Orange: An Alternative to DMAA
On April 27, 2012, the U.S. Food and Drug Administration issued a warning letter to 10 fitness supplement companies selling weight loss and sports nutrition products containing the controversial ingredient, DMAA. The FDA further warned that DMAA was not a botanical ingredient since it is synthetically produced and therefore ineligible to be used as an active ingredient in a dietary supplement. Citing several harmful effects of DMAA, the FDA ordered said companies to immediately take remedial steps to address these concerns.1
What are the Side Effects of DMAA?DMAA, commonly sold as 1,3- dimethylamylamine, methylhexanamine, or geranium extract, is a synthetic substance popularly used in bodybuilding and weight-loss products. DMAA is said to have potentially fatal side effects on cardiovascular health leading to events such as shortness of breath, tightening of chest, heart attacks and elevated blood pressure. After 42 public complaints, the FDA issued a warning linking DMAA to serious health effects on the nervous system and psychiatric disorders as well as death.2The controversy: Is DMAA a Drug?The controversy over DMAA doesn’t end here. Is DMAA a botanical substance or synthetic? Since DMAA is manufactured in laboratories, many experts believe it is not a botanical substance, but an amphetamine-like substance which should be treated as a drug. It should undergo rigorous testing standards and be approved by the FDA as a drug. In light of these heated controversies, supplement business owners are busy looking for safer substitutes for DMAA in their weight-loss and sport nutrition formulations. One option is to substitute DMAA with the herbal substance, bitter orange, as their benefits are similar.Health Benefits of Bitter OrangeBitter orange is prepared from the bitter orange fruit, botanically known as Citrus aurantium. For centuries the Chinese and the tribes of the Amazon rainforests have used it to treat indigestion, nausea and constipation. Bitter orange supplements are believed to treat heartburn, appetite loss, nasal congestion, weight loss and fungal infections. The two bioactive ingredients in bitter orange are synephrine and octopamine. Both are stimulants that help to increase rate of body metabolism.3However, because its chemical structure is similar to ephedra, some people mistakenly believe that bitter orange has the same negative side effects as ephedra. Bitter orange contains the active compound p-synephrine. Does p-synephrine have the same dangerous side effects as ephedra? Let’s find out.Is P-Synephrine Dangerous?Hundreds of studies report the safety and efficacy of p-synephrine. An abstract from “A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects” published in the 2011 Volume of Oxidative Medicine and Cellular Longevity states:4“Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of p-synephrine are widely assumed to be similar to those of ephedrine, m-synephrine (phenylephrine), and endogenous amine neurotransmitters as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-spread consumption of p-synephrine in the form of dietary supplements as well as in various Citrus foods and juices. This paper summarizes the adrenoreceptor binding characteristics of p-synephrine relative to m-synephrine, norepinephrine, and other amines as related to the observed pharmacological effects.”Another extensive study highlights the reasons for the confusion about bitter orange:5“Current confusion regarding the safety and efficacy of bitter orange extract and p-synephrine is clouded by multiple issues, including the use of complex mixtures of ingredients in products that include bitter orange extract, the release of misleading information by governmental agencies, and misunderstandings regarding the isomeric forms of synephrine and their differing pharmacological properties. In addition, the projected warnings regarding cardiovascular risks are extrapolated from studies involving m-synephrine and ephedrine which are not components of bitter orange extract, and from studies involving the intravenous administration of p-synephrine at concentrations that are not attained by oral ingestion in foods or supplements.”The study goes on to reveal a few more valid points: 6“A final consideration regarding the safety of p-synephrine is the exposure of millions of people who daily consume, without ill effect, various juices and food products as marmalade from Citrus species asSeville orange, grapefruit, mandarin and other orange-related species that contain p-synephrine.7A typical sweet orange contains about 6mg p-synephrine.8A wide variety of Citrus juices contain approximately 5mg p-synephrine per 8 ounce glass.9A U.S. Department of Agriculture study of the p-synephrine content of mandarin orange juice from 10 different groves in California found that the p-synephrine content ranged from 73 to 158 mg/L, with an overall mean of 93 mg/L.10Another study has shown the juice from Clementines, a variety of mandarin oranges, contained on average of 114mg p-synephrine/L while Marrs sweet oranges yielded 85 mg/L.11Therefore, consuming an 8 ounce glass of mandarin orange juice may deliver as much as 40mgP-synephrine, similar to the amount of p-synephrine in the typical dietary supplement.”Bitter orange: An effective substitute forDMAAin your supplement formulations.Bitter orange is the ideal replacement for DMAA in your weight loss or sports nutrition products. Find a reliable LINK REMOVED supplement manufacturerEND LINK REMOVED that has a track record of contract manufacturing success. A supplement manufacturer with an award-wining history will ensure you get products that stand out in the marketplace. Look for optional manufacturing solutions such as label design, packaging options, order fulfillment and storage options that can it make it convenient for you to manufacture your product.Resources:FDA challenges marketing of DMAA products for lack of safety evidence, April 27, 2012. fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302133.htmIbid.Bitter Orange, Drugs.com. drugs.com/npp/bitter-orange.htmlA Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects, Oxidative Medicine and Cellular Longevity Volume 2011 (2011), Article ID 482973, 9 pages, doi:10.1155/2011/482973. hindawi.com/journals/oximed/2011/482973/abs/The Safety of Citrus aurantium (Bitter Orange) and its Primary Protoalkaloid p?Synephrine, PHYTOTHERAPY RESEARCH, Phytother. Res. (2011), Published online in Wiley Online Library(wileyonlinelibrary.com) DOI: 10.1002/ptr.3490. nutratechinc.com/advz/UploadedFiles/Phyto%20Research%200411.pdfIbidPellati et al.,2002, 2004, 2005; Blumenthal, 2004; Avula et al., 2005; Mattoli et al., 2005; Dragull et al., 2008; Arbo et al., 2008; Roman et al., 2008.Mattoli et al., 2005.Blumenthal, 2004; Pellati et al., 2002, 2004, 2005.Dragull et al., 2008.Uckoo et al.,2010. Nutricap Labs is a full service LINK REMOVED contract manufacturing nutritional supplementsEND LINK REMOVED . We primarily manufacture GMP-certified capsules, powders, liquids and creams.
============================== NEW ARTICLE ==============================Product Liability Insurers To Exclude DMAA From Coverage
(Los Angeles, CA): More trouble for DMAA, the controversial ingredient in many pre-workout sports nutrition and weight loss products.
Greg Doherty, Practice Leader of the dietary supplement insurance division of Poms & Associates Insurance Brokers, Inc, today announced that two of the handful of companies offering product liability coverage to the dietary supplement industry will soon be adding DMAA to their respective “ingredient exclusion†list.
“I predicted this over a year ago, and now it’s happening†says Doherty. “There has been too much negative press lately on DMAA, and eventually it was bound to catch the eye of some of the insurance company underwriters. Two carriers will now exclude it, although one has hinted that they may offer coverage for products containing DMAA on a “carveback†basis, which means that based on the type of products being sold, the dosage of DMAA and the volume of DMAA sales as a percentage of overall sales, this carrier might offer DMAA coverage for an additional premium. The key word is ‘might.’ “
Doherty further noted that as ephedra alkoloids got more and more bad press, these “carvebacks†granting coverage were available, but eventually coverage was excluded altogether. Subsequently, the insurance companies paid out millions of dollars for ephedra claims, and they have not forgotten that fact.
“As of right now coverage is still available for DMAA products from other insurers, but my opinion is that the window is closing. It’s really the ephedra insurance coverage story all over again.â€
“Companies currently selling DMAA and want it to be covered in the future face a real dilemma,†Doherty adds. “Because of the claims made nature of product liability policies for dietary supplement companies, the product you sell today will likely not produce a claim until some date in the future. If your future policy has a DMAA exclusion, and that claim rolls in, there won’t be coverage, even though the policy in your file today covers DMAA.â€
When it comes to an in-depth understanding of the dietary supplement industry, Greg Doherty is Poms & Associates’ mega-multi vitamin of knowledge, experience and reliability.
Just like you've heard the radio commercial say, “When banks compete you win.†we say “When insurance companies compete for your business, you win.†If you’re in the supplement industry, and want to be sure that your company has the best possible product liability insurance, and experience the personal service you deserve, call Greg directly at 818-449-9317
Greg M. Doherty is a commercial insurance broker based in Los Angeles. He is a specialist on the subject of DMAA exclusion. Doherty can be reached at (818) 449-9317 or gdoherty@pomsassoc.com Website: http://www.gregdoherty.net
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