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Here There Everywhere and Back to Nowhere...

We are not entirely human

By Maggie Fox, Health and Science Correspondent

WASHINGTON (Reuters) - We may not be entirely human, gene experts said on Thursday after studying the DNA of hundreds of different kinds of bacteria in the human gut.

Bacteria are so important to key functions such as digestion and the immune system that we may be truly symbiotic organisms -- relying on one another for life itself, the scientists write in Friday's issue of the journal Science.

Their findings suggest that studying bacteria native to our bodies may provide important clues to disease, nutrition, obesity and how well drugs will work in individuals, said the team at The Institute for Genomic Research, commonly known as TIGR, in Maryland.

"We are somehow like an amalgam, a mix of bacteria and human cells. There are some estimates that say 90 percent of the cells on our body are actually bacteria," Steven Gill, a molecular biologist formerly at TIGR and now at the State University of New York in Buffalo, said in a telephone interview.

"We're entirely dependent on this microbial population for our well-being. A shift within this population, often leading to the absence or presence of beneficial microbes, can trigger defects in metabolism and development of diseases such as inflammatory bowel disease."

Scientists have long known that at least 50 percent of human feces, and often more, is made up of bacteria from the gut. Bacteria start to colonize the intestines and colon shortly after birth, and adults carry up to 100 trillion microbes, representing more than 1,000 different species.

They are not just freeloading. They help humans to digest much of what we eat, including some vitamins, sugars, and fiber. They also synthesize vitamins that people cannot.

"Humans have evolved for million of years with these bacteria. And they provide essential functions," Gill said.

GERM SURPRISE

Gill and his team sequenced the DNA in feces donated by three adults. They found a surprising amount of it came from bacteria.

They compared the gene sequences to those from known bacteria and to the human genome and found this so-called colon microbiome -- the entire sum of genetic material from microbes in the lower gut -- includes more than 60,000 genes.

That is twice as many as found in the human genome.

"Of all the DNA sequences in that material, only 1 to 5 percent of it was not bacterial," Gill said.

"We were surprised."

They also found a surprising number of Archaea, also known as archaebacteria, which are genetically distinct from bacteria but which are also one-celled organisms often found in extreme environments such as hot springs.

The donors were healthy adults. None had taken antibiotics for a year, as these drugs are known to disturb the bacteria in the body.

Gill said his team hopes now to make a comparison of the gut bacteria from different people.

"The ideal study would be to compare 20 people, 30 people from different ethnic backgrounds, different diets, drinkers, smokers, and so on, because I think there are going to be distinct differences," Gill said.

These bacteria almost certainly help break down drugs that people take and studying the effects of different populations of the microbes might provide clues to treating different people with various medications.

The next study will focus on the bacteria in the mouth, Gill said. There are at least 800 species in the mouth and maybe more, Gill said.

Source: http://news.yahoo.com/s/nm/20060601/sc_nm/bacteria_dc

Scientists discover 8 new species

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By ARON HELLER, Associated Press Writer

JERUSALEM - Israeli scientists have discovered an ancient ecosystem containing eight previously unknown species in a lake inside a cave, where they were completely sheltered from the outside world for millions of years.

The newly discovered crustaceans and invertebrates were found last month in a cave near the city of Ramle in central
Israel, team leader Amos Frumkin announced Thursday.

"This is a very unique ecosystem that is completely isolated from the surface," said Frumkin, a cave researcher in the geography department of Hebrew University in Jerusalem.

The cave, located 328 feet below ground in a limestone quarry, includes tunnels that extend about a mile and a half. Inside, a large underground lake holds the previously unknown species, some similar to scorpions and shrimp.

Allen G. Collins, a research fellow at the
Smithsonian Institution in Washington, said the find "underscores how little we know about life on our planet and how important it is to keep looking."

"I imagine this is a unique situation, to have a cave system with both marine and freshwater systems, and it is quite interesting in an underground situation," he said. "The scorpion-like creatures as well as the shrimp-like creatures that were found are unique."

The animals had been completely sheltered from the outside world by a thick layer of chalk that was impenetrable to water or exterior nutrients, Frumkin said.

Aside from one scorpion-like creature, all other species discovered were found alive. None were more than two inches long.

Frumkin said similar caves have been discovered in Romania and Mexico, but none were as isolated. Unlike most animals, which depend on the photosynthesis food chain, the newly discovered species live off a completely independent and self-sustaining ecosystem.

Israel Naaman, Frumkin's research assistant, made the initial discovery. He had been conducting a survey of caves when he came across a small hole that just kept growing.

"I thought it was just a small hole and I couldn't believe what I had found; surprise after surprise," he said.

When one of the volunteer staff crouched down to measure the temperature of the warm, sulfuric water he suddenly jumped up and yelled "there is something moving here."

Naaman acknowledged the species were likely endangered from oxygen exposure during the discovery process but said he was confident in the scientific importance of the find. He said he believes further exploration will reveal additional new life forms.

The Israeli researchers have shared their findings with international experts for further review and classification and hope to publish their conclusions soon.

The limestone cave is believed to be the second-largest in Israel. In order to explore it, researchers had to climb ropes and crawl through most of it. Due to its scientific significance and the fact that it is located inside an active quarry, the cave is now closed to visitors.

Source: http://news.yahoo.com/s/ap/20060601/ap_on_sc/israel_lost_world

Quotes For June

In the beginning there was nothing. God said, 'Let there be light!' And there was light. There was still nothing, but you could see it a whole lot better.
Ellen DeGeneres

Be audacious. Be crazy in your own way, with that maddness in the eyes of man that is wisdom in the eyes of god.
Arnaud Desjardins

If I'd known I'd live this long, I'd have taken better care of myself.
Unknown

One of the good things about getting older is you find you're more interesting than most of the people you meet.
Lee Marvi

Doing research on the Web is like using a library assembled piecemeal by pack rats and vandalized nightly.
Roger Ebert

METEOR WATCH

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On May 31st, Earth will pass about five million miles from the dusty orbit of crumbling comet 73P/Schwassmann Wachmann 3. The great distance means a meteor shower is unlikely; but 73P is such a strange comet that even the unlikely is possible. Be alert for meteors slowly cutting across the sky in the nights ahead...

Arctic "Noah's Ark" vault to protect world's seeds

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By Alister Doyle, Environment Correspondent

OSLO (Reuters) - A frozen "Noah's Ark" to safeguard the world's crop seeds from cataclysms will be built on a remote Arctic island off Norway, the Norwegian government said on Tuesday.
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Construction of the Global Seed Vault, in a mountainside on the island of Svalbard 1,000 km (600 miles) from the North Pole, would start in June with completion due in September 2007.

"Norway will by this contribute to the global system for ensuring the diversity of food plants. A Noah's Ark on Svalbard if you will," Norwegian Agriculture and Food Minister Terje Riis-Johansen said in a statement.

The doomsday vault would be built near Longyaerbyen, Svalbard's main village, with space for three million seed varieties. It would store seeds including rice, wheat, and barley as well as fruits and vegetables.

It would be a remote Arctic back-up for scores of other seed banks around the world, which may be more vulnerable to risks ranging from nuclear war to mundane power failures.

"Gene banks can be affected by shutdowns, natural disasters, wars or simply a lack of money," Riis-Johansen said.

Loss of genetic diversity would mean losing a part of cultural heritage. "We also reduce the ability of agriculture to meet new challenges relating to climate change, population increase, and so on," he said.

The seeds would be stored at -18 Celsius (-0.40F). If the power failed, the seeds would probably stay frozen.

"The temperature there is around -3C, -4C in the summer but we believe that even if the freezers broke down a suitable temperature would last for months," said Grethe Helene Evjen, a senior adviser at the Agriculture Ministry.

"This will be primarily a duplicate storage for plant seeds already stored elsewhere," she told Reuters. Seeds would remain the property of nations making deposits.

Norway would provide 30 million Norwegian crowns ($4.94 million) to build the vault. Prime Minister Jens Stoltenberg would mark the start of construction during a meeting of prime ministers from the Nordic region on the island on June 19.

Norway has long talked of building the Arctic seed vault without previously taking action. For about 15 years some varieties of seed have been stored in a disused Svalbard mine under a plan to see if they can germinate after 100 years.

Norway has worked with the U.N.'s Food and Agriculture Organization on the plans. It would also get financial support from the Global Crop Diversity Trust to help poor countries use the storage.

Source: http://news.yahoo.com/s/nm/20060530/sc_nm/environment_seeds_dc

Was Albert Einstein A Space Alien?

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Albert Einstein was exhausted. For the third night in a row, his baby son Hans, crying, kept the household awake until dawn. When Albert finally dozed off … it was time to get up and go to work. He couldn't skip a day. He needed the job to support his young family.

Walking briskly to the Patent Office, where he was a "Technical Expert, Third Class," Albert worried about his mother. She was getting older and frail, and she didn't approve of his marriage to Mileva. Relations were strained. Albert glanced at a passing shop window. His hair was a mess; he had forgotten to comb it again.

Work. Family. Making ends meet. Albert felt all the pressure and responsibility of any young husband and father.

To relax, he revolutionized physics.

In 1905, at the age of 26 and four years before he was able to get a job as a professor of physics, Einstein published five of the most important papers in the history of science - all written in his "spare time." He proved that atoms and molecules existed. Before 1905, scientists weren't sure about that. He argued that light came in little bits (later called "photons") and thus laid the foundation for quantum mechanics. He described his theory of special relativity: space and time were threads in a common fabric, he proposed, which could be bent, stretched and twisted.

Oh, and by the way, E=mc2.

Before Einstein, the last scientist who had such a creative outburst was Sir Isaac Newton. It happened in 1666 when Newton secluded himself at his mother's farm to avoid an outbreak of plague at Cambridge. With nothing better to do, he developed his Theory of Universal Gravitation.

For centuries historians called 1666 Newton's annus mirabilis, or "miracle year." Now those words have a different meaning: Einstein and 1905. The United Nations has declared 2005 "The World Year of Physics" to celebrate the 100th anniversary of Einstein's annus mirabilis.

Modern pop culture paints Einstein as a bushy-haired superthinker. His ideas, we're told, were improbably far ahead of other scientists. He must have come from some other planet - maybe the same one Newton grew up on.

"Einstein was no space alien," laughs Harvard University physicist and science historian Peter Galison. "He was a man of his time." All of his 1905 papers unraveled problems being worked on, with mixed success, by other scientists. "If Einstein hadn't been born, [those papers] would have been written in some form, eventually, by others," Galison believes.

What's remarkable about 1905 is that a single person authored all five papers, plus the original, irreverent way Einstein came to his conclusions.

For example: the photoelectric effect. This was a puzzle in the early 1900s. When light hits a metal, like zinc, electrons fly off. This can happen only if light comes in little packets concentrated enough to knock an electron loose. A spread-out wave wouldn't do the photoelectric trick.

The solution seems simple - light is particulate. Indeed, this is the solution Einstein proposed in 1905 and won the Nobel Prize for in 1921. Other physicists like Max Planck (working on a related problem: blackbody radiation), more senior and experienced than Einstein, were closing in on the answer, but Einstein got there first. Why?

It's a question of authority.

"In Einstein's day, if you tried to say that light was made of particles, you found yourself disagreeing with physicist James Clerk Maxwell. Nobody wanted to do that," says Galison. Maxwell's equations were enormously successful, unifying the physics of electricity, magnetism and optics. Maxwell had proved beyond any doubt that light was an electromagnetic wave. Maxwell was an Authority Figure.

Einstein didn't give a fig for authority. He didn't resist being told what to do, not so much, but he hated being told what was true. Even as a child he was constantly doubting and questioning. "Your mere presence here undermines the class's respect for me," spat his 7th grade teacher, Dr. Joseph Degenhart. (Degenhart also predicted that Einstein "would never get anywhere in life.") This character flaw was to be a key ingredient in Einstein's discoveries.

"In 1905," notes Galison, "Einstein had just received his Ph.D. He wasn't beholden to a thesis advisor or any other authority figure." His mind was free to roam accordingly.

In retrospect, Maxwell was right. Light is a wave. But Einstein was right, too. Light is a particle. This bizarre duality baffles Physics 101 students today just as it baffled Einstein in 1905. How can light be both? Einstein had no idea.

That didn't slow him down. Disdaining caution, Einstein adopted the intuitive leap as a basic tool. "I believe in intuition and inspiration," he wrote in 1931. "At times I feel certain I am right while not knowing the reason."

Although Einstein's five papers were published in a single year, he had been thinking about physics, deeply, since childhood. "Science was dinner-table conversation in the Einstein household," explains Galison. Albert's father Hermann and uncle Jakob ran a German company making such things as dynamos, arc lamps, light bulbs and telephones. This was high-tech at the turn of the century, "like a Silicon Valley company would be today," notes Galison. "Albert's interest in science and technology came naturally."

Einstein's parents sometimes took Albert to parties. No babysitter was required: Albert sat on the couch, totally absorbed, quietly doing math problems while others danced around him. Pencil and paper were Albert's GameBoy!

He had impressive powers of concentration. Einstein's sister, Maja, recalled "...even when there was a lot of noise, he could lie down on the sofa, pick up a pen and paper, precariously balance an inkwell on the backrest and engross himself in a problem so much that the background noise stimulated rather than disturbed him."

Einstein was clearly intelligent, but not outlandishly more so than his peers. "I have no special talents," he claimed, "I am only passionately curious." And again: "The contrast between the popular assessment of my powers ... and the reality is simply grotesque." Einstein credited his discoveries to imagination and pesky questioning more so than orthodox intelligence.

Later in life, it should be remembered, he struggled mightily to produce a unified field theory, combining gravity with other forces of nature. He failed. Einstein's brainpower was not limitless.

Neither was Einstein's brain. It was removed without permission by Dr. Thomas Harvey in 1955 when Einstein died. He probably expected to find something extraordinary: Einstein's mother Pauline had famously worried that baby Einstein's head was lopsided. (Einstein's grandmother had a different concern: "Much too fat!") But Einstein's brain looked much like any other, gray, crinkly, and, if anything, a trifle smaller than average.

Detailed studies of Einstein's brain are few and recent. In 1985, for instance, Prof. Marian Diamond of UC Berkeley reported an above-average number of glial cells (which nourish neurons) in areas of the left hemisphere thought to control math skills. In 1999, neuroscientist Sandra Witelson reported that Einstein's inferior parietal lobe, an area related to mathematical reasoning, was 15% wider than normal. Furthermore, she found, the Slyvian fissure, a groove that normally extends from the front of the brain to the back, did not go all the way in Einstein's case. Might this have allowed greater connectivity among different parts of Einstein's brain?

No one knows.

Not knowing. It makes some researchers feel uncomfortable. It exhilarated Einstein: "The fairest thing we can experience is the mysterious," he said. "It is the fundamental emotion that stands at the cradle of true art and true science."

It's the fundamental emotion that Einstein felt, walking to work, awake with the baby, sitting at the dinner table. Wonder beat exhaustion, every day.

Source: http://www.firstscience.com/site/articles/alberteinstein1.asp

Which Came First? The Chicken Or The Egg?

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Chicken and egg debate unscrambled...

Egg came first, 'eggsperts' agree

LONDON, England -- It's a question that has baffled scientists, academics and pub bores through the ages: What came first, the chicken or the egg?

Now a team made up of a geneticist, philosopher and chicken farmer claim to have found an answer. It was the egg.

Put simply, the reason is down to the fact that genetic material does not change during an animal's life.

Therefore the first bird that evolved into what we would call a chicken, probably in prehistoric times, must have first existed as an embryo inside an egg.

Professor John Brookfield, a specialist in evolutionary genetics at the University of Nottingham, told the UK Press Association the pecking order was clear.

The living organism inside the eggshell would have had the same DNA as the chicken it would develop into, he said.

"Therefore, the first living thing which we could say unequivocally was a member of the species would be this first egg," he added. "So, I would conclude that the egg came first."

The same conclusion was reached by his fellow "eggsperts" Professor David Papineau, of King's College London, and poultry farmer Charles Bourns.

Mr Papineau, an expert in the philosophy of science, agreed that the first chicken came from an egg and that proves there were chicken eggs before chickens.

He told PA people were mistaken if they argued that the mutant egg belonged to the "non-chicken" bird parents.

"I would argue it is a chicken egg if it has a chicken in it," he said.

"If a kangaroo laid an egg from which an ostrich hatched, that would surely be an ostrich egg, not a kangaroo egg."

Bourns, chairman of trade body Great British Chicken, said he was also firmly in the pro-egg camp.

He said: "Eggs were around long before the first chicken arrived. Of course, they may not have been chicken eggs as we see them today, but they were eggs."

The debate, which may come as a relief to those with argumentative relatives, was organized by Disney to promote the release of the film "Chicken Little" on DVD.

Source: http://www.cnn.com/2006/TECH/science/05/26/chicken.egg/index.html?section=cnn_space
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