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In addition to the projections there are ascending and descending - from brain centers to notsitseptivnym cells. The existence of such a top-down control is confirmed by the establishment of the fact that the sensation of pain is eliminated upon stimulation of many parts of the brain. Among them, the kernel kontrlateralnogo bridge hypothalamic nucleus, the nucleus and the nucleus large seam somatosensory cortex. Stimulation of these sites leaves animals active and reactive, but insensitive to pain incentives.Diazepam (Valium) is used to treat anxiety disorders. A similar phenomenon is shown, and people suffering from chronic pain, this "caused by" analgesia allows the investigation of anatomy and physiology of descending control. It was found that the path from the highest levels are in the PAS and the rostral ventromedialny medulla oblongata, and thence through dorzolateralny tract white matter of spinal cord cells notsitseptivnym to the dorsal horn gray matter. Many of the fibers of the descending path is serotonergicheskimi. Stimulation of the ways to reduce the activity of dorsal horn cells notsitseptivnyh and eliminates animal behavioral responses to painful stimuli. Implantation of electrodes in the PCA person with chronic pain, reduce suffering, but had little effect on the sense of touch and temperature sensitivity.