Managing email was a nightmare 5 years ago, with a desktop computer, mail stored on a server partition, and a laptop for travel. I finally settled on a more powerful laptop as my sole computer. I moved my Outlook database from the server to my laptop (small company), and I download everything to this single database whether in the office, at home, or traveling. Now, I occasionally copy the database to a personal backup partition on the company server (certainly less often that I should).
Sailing is my hobby. For quite some time I received sailing email into a separate Outlook database, loaded along with my main business mail data. Sail-mail during business hours is a distraction. I finally got a different email address and started managing sail-mail in Express. Even so, I find about 90% of my computing hours, I have 3 applications running, Outlook, Express and Opera.
Since my 500MB business database can be left behind in Outlook, sail-mail gave me a perfect opportunity to test M2. So, sail-mail is now captured into M2. I was in a rush to make the change from Express to M2, since I was changing to a new laptop. I tried importing into M2 with no success - so the hobby mail was just reformatted to oblivion, and M2 is now my sail-mailer.
Now I have 2 applications active most times, Outlook and Opera-M2.